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Fig. 4 | Molecular Brain

Fig. 4

From: Development of a rabies virus-based retrograde tracer with high trans-monosynaptic efficiency by reshuffling glycoprotein

Fig. 4

Trans-monosynaptic tracing efficiency of RV with the help of various glycoproteins (ooG, oG and B19G). a Coronal sections were collected and imaged. Representative images of EnvA-RV-mRuby3 (EnvA-RV844) retrogradely trans-monosynaptic tracing from the vHPC to PVA with the help of two AAV helpers. b and c Convergence indices for long-distance projection inputs in PVA (b) and MS (c) using the ooG, oG, and B19G, respectively. The one-way ANOVA was conducted to compare the difference of RV tracing efficiency using different G genes (GraphPad Prism 5 software). Three mice for each G gene. “***” Represents a statistically significant difference. Definitely, the p-values of the ooG versus oG, ooG versus B19G and oG versus B19G are less than 0.0001, respectively. Error bars indicate the standard error of the mean from the three independent experiments

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Molecular Brain

ISSN: 1756-6606