Skip to main content
Fig. 1 | Molecular Brain

Fig. 1

From: Meningitic Escherichia coli α-hemolysin aggravates blood–brain barrier disruption via targeting TGFβ1-triggered hedgehog signaling

Fig. 1

Meningitic E. coli infection broke the BBB integrity and caused death in challenged mice. A The expression of ZO-1 on BMECs of the mice in response to RS218 infection via IF. The BMECs were marked with CD31 in green. Scale bars indicated 50 μm. B Evan’s blue assay assessing the BBB permeability upon RS218 infection (n = 3). C Effects of the rTGFβ1 pre-treatment (for 12 h) or co-treatment (synchronously) (at 1 µg/kg) on the survival of mice challenged with RS218 (n = 10). Survival data were collected and shown as Kaplan–Meier survival curves, and the statistical analysis was carried out by Log-rank (Mantel–Cox) test. *p < 0.05

Back to article page

Molecular Brain

ISSN: 1756-6606