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Table2 Pathway enrichment analysis for DEGs

From: Transcriptomic profiling of high- and low-spiking regions reveals novel epileptogenic mechanisms in focal cortical dysplasia type II patients

Pathway enrichment analysis
Source Term_name Term_id Adjusted_p_value Negative_log10_of_adjusted_p_value Term_size Query_size Intersection_size Effective_domain_size Intersections
A: Maximum vs autopsy
GO:BP Myelination GO:0042552 0.00168791 2.77265077 139 43 6 17906 PLP1, MAG, UGT8, CD9, PLLP, SH3TC2
GO:BP Ensheathment of neurons GO:0007272 0.00191291 2.71830651 142 43 6 17906 PLP1, MAG, UGT8, CD9, PLLP, SH3TC2
GO:BP Axon ensheathment GO:0008366 0.00191291 2.71830651 142 43 6 17906 PLP1, MAG, UGT8, CD9, PLLP, SH3TC2
GO:BP Oligodendrocyte development GO:0014003 0.04500542 1.34673519 47 22 3 17906 PLP1, MAG, CD9
B: Maximum vs minimum
GO:BP Ensheathment of neurons GO:0007272 1.44E−11 10.8420434 142 158 17 17906 PLP1,KLK6,UGT8,CLDN11,ASPA,SH3TC2,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,GAL3ST1,ABCA2,PLLP,BCAS1,SOX10
GO:BP Axon ensheathment GO:0008366 1.44E−11 10.8420434 142 158 17 17906 PLP1,KLK6,UGT8,CLDN11,ASPA,SH3TC2,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,GAL3ST1,ABCA2,PLLP,BCAS1,SOX10
GO:BP Myelination GO:0042552 1.72E−10 9.76340897 139 158 16 17906 PLP1,KLK6,UGT8,ASPA,SH3TC2,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,GAL3ST1,ABCA2,PLLP,BCAS1,SOX10
GO:BP Oligodendrocyte differentiation GO:0048709 9.24E−09 8.03431166 101 158 13 17906 SLC45A3,PLP1,ASPA,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,ABCA2,BOK,DAAM2,SOX10
GO:BP Axon ensheathment in central nervous system GO:0032291 2.50E−08 7.60287967 23 158 8 17906 PLP1,ASPA,MAG,NKX6-2,FA2H,CNTN2,ABCA2,SOX10
GO:BP Central nervous system myelination GO:0022010 2.50E−08 7.60287967 23 158 8 17906 PLP1,ASPA,MAG,NKX6-2,FA2H,CNTN2,ABCA2,SOX10
GO:BP Oligodendrocyte development GO:0014003 4.89E−07 6.311047 47 158 9 17906 PLP1,ASPA,MAG,NKX6-2,FA2H,CNTN2,CD9,ABCA2,SOX10
GO:BP Gliogenesis GO:0042063 2.13039E−05 4.67154125 310 134 15 17906 LRP2,SLC45A3,PLP1,ASPA,SH3TC2,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,CERS2,ABCA2,BOK,DAAM2
GO:BP Glial cell differentiation GO:0010001 2.48143E−05 4.60529884 226 158 14 17906 SLC45A3,PLP1,ASPA,SH3TC2,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,ABCA2,BOK,DAAM2,SOX10
GO:BP Glial cell development GO:0021782 9.74491E−05 4.01122223 121 109 9 17906 PLP1,ASPA,SH3TC2,MAG,NKX6-2,FA2H,CNTN2,CD9,ABCA2
GO:BP Sphingolipid biosynthetic process GO:0030148 0.000460392 3.33687211 105 109 8 17906 UGT8,ELOVL1,PLPP2,FA2H,P2RX7,CERS2,GAL3ST1,ABCA2
GO:BP Regulation of gliogenesis GO:0014013 0.000494076 3.30620614 132 158 10 17906 LRP2,SLC45A3,ASPA,MAG,NKX6-2,CNTN2,TMEM98,CERS2,DAAM2,SOX10
GO:BP Nervous system development GO:0007399 0.000672174 3.17251812 2432 160 46 17906 LRP2,AQP1,SLC45A3,MOG,PLP1,KLK6,UGT8,CLDN11,SPP1,GLDN,GJB1,ASPA,MOBP,SH3TC2,C21ORF91,MAG,S1PR5,NKX6-2,FA2H,CNTN2,DOCK10,TMEM98,CD9,USH1C,SEMA4D,TNC,NDE1,CERS2,MYO1D,GAL3ST1,ABCA2,PLLP,ZNF536,SEMA6A,BOK,SYNJ2,SEMA3B,MAN2A1,BCAS1,DAAM2,KIF13B,WHRN,FRYL,SFRP1,SOX10,MAP4K4
GO:BP Neurogenesis GO:0022008 0.000902115 3.04473832 1679 166 37 17906 LRP2,SLC45A3,PLP1,KLK6,UGT8,SPP1,GLDN,ASPA,SH3TC2,C21ORF91,MAG,S1PR5,NKX6-2,FA2H,CNTN2,DOCK10,TMEM98,CD9,USH1C,SEMA4D,TNC,NDE1,CERS2,ABCA2,ZNF536,SEMA6A,BOK,SEMA3B,MAN2A1,DAAM2,KIF13B,WHRN,FRYL,SFRP1,SOX10,MAP4K4,LTK
GO:BP Cell development GO:0048468 0.000919176 3.03660132 2215 160 43 17906 LRP2,SLC45A3,PLP1,KLK6,UGT8,SPP1,GLDN,ASPA,TYMS,DYSF,SH3TC2,DOCK5,C21ORF91,MAG,S1PR5,LDB3,CAPN3,NKX6-2,FA2H,CNTN2,PIP4K2A,DOCK10,TMEM98,CD9,USH1C,SEMA4D,TNC,CERS2,ABCA2,TJP2,ZNF536,SEMA6A,SEMA3B,MAN2A1,CLIC4,CFL2,DAAM2,KIF13B,WHRN,FRYL,SFRP1,SOX10,MAP4K4
GO:BP Regulation of glial cell differentiation GO:0045685 0.001515404 2.81947151 73 79 6 17906 SLC45A3,ASPA,MAG,NKX6-2,CNTN2,TMEM98
GO:BP Regeneration GO:0031099 0.003378801 2.4712374 209 96 9 17906 KLK6,SPP1,TYMS,DYSF,MAG,CAPN3,CD9,TNC,CERS2
GO:BP Ceramide biosynthetic process GO:0046513 0.00370985 2.4306437 64 105 6 17906 UGT8,ELOVL1,FA2H,P2RX7,CERS2,GAL3ST1
GO:BP Membrane lipid biosynthetic process GO:0046467 0.005378894 2.26930705 145 109 8 17906 UGT8,ELOVL1,PLPP2,FA2H,P2RX7,CERS2,GAL3ST1,ABCA2
GO:BP Negative regulation of neurogenesis GO:0050768 0.006339891 2.19791821 303 160 13 17906 SPP1,MAG,NKX6-2,CNTN2,TMEM98,SEMA4D,CERS2,ZNF536,SEMA6A,SEMA3B,DAAM2,SOX10,MAP4K4
GO:BP Galactosylceramide biosynthetic process GO:0006682 0.007164655 2.14480471 6 105 3 17906 UGT8,FA2H,GAL3ST1
GO:BP Galactolipid biosynthetic process GO:0019375 0.007164655 2.14480471 6 105 3 17906 UGT8,FA2H,GAL3ST1
GO:BP Regulation of neurogenesis GO:0050767 0.007966259 2.09874557 856 166 23 17906 LRP2,SLC45A3,KLK6,SPP1,ASPA,C21ORF91,MAG,S1PR5,NKX6-2,CNTN2,TMEM98,SEMA4D,CERS2,ZNF536,SEMA6A,SEMA3B,MAN2A1,DAAM2,KIF13B,SFRP1,SOX10,MAP4K4,LTK
GO:BP Cellular component morphogenesis GO:0032989 0.010095286 1.99588137 1177 160 27 17906 LRP2,UGT8,ENPP2,SPP1,ERMN,DOCK5,CDH19,MAG,LDB3,CAPN3,CNTN2,P2RX7,DOCK10,CD9,SEMA4D,WIPF1,ABCA2,CDC42EP1,SEMA6A,SEMA3B,PHLDB1,CLIC4,CFL2,KIF13B,WHRN,FRYL,MAP4K4
GO:BP Sphingolipid metabolic process GO:0006665 0.011698213 1.93188047 161 109 8 17906 UGT8,ELOVL1,PLPP2,FA2H,P2RX7,CERS2,GAL3ST1,ABCA2
GO:BP Negative regulation of nervous System development GO:0051961 0.013118962 1.88210053 324 160 13 17906 SPP1,MAG,NKX6-2,CNTN2,TMEM98,SEMA4D,CERS2,ZNF536,SEMA6A,SEMA3B,DAAM2,SOX10,MAP4K4
GO:BP Regulation of cell projection organization GO:0031344 0.015838735 1.8002795 704 166 20 17906 ANLN,KLK6,ENPP2,SPP1,ERMN,C21ORF91,MAG,CNTN2,P2RX7,USH1C,SEMA4D,CERS2,PLD1,CDC42EP1,SEMA6A,SEMA3B,KIF13B,SFRP1,MAP4K4,LTK
GO:BP System development GO:0048731 0.018013177 1.74440968 5020 167 73 17906 LRP2,AQP1,SLC45A3,MOG,PLP1,ANLN,DMRT2,PCSK6,KLK6,UGT8,CLDN11,ENPP2,SPP1,GLDN,GJB1,ASPA,TYMS,TF,MOBP,DYSF,ELOVL1,SH3TC2,ADAMTS1,C21ORF91,MAG,S1PR5,LDB3,CAPN3,NKX6-2,FA2H,CNTN2,PIP4K2A,P2RX7,ATF3,DOCK10,TMEM98,CD9,CRYAB,USH1C,SEMA4D,TNC,NDE1,CERS2,MYO1D,TGFA,GAL3ST1,ABCA2,PLLP,ZNF536,RASSF2,SEMA6A,BOK,SYNJ2,SEMA3B,PHLDB1,MAN2A1,CLIC4,CFL2,BCAS1,DAAM2,KIF13B,WHRN,GLIPR2,FGF1,MCAM,FRYL,PLAAT3,SFRP1,SOX10,MAP4K4,COL5A2,LTK,CARTPT
GO:BP Glycosylceramide biosynthetic process GO:0046476 0.019890103 1.70136298 8 105 3 17906 UGT8,FA2H,GAL3ST1
GO:BP Central nervous system development GO:0007417 0.022798319 1.64209718 1031 158 24 17906 LRP2,AQP1,SLC45A3,MOG,PLP1,KLK6,UGT8,ASPA,C21ORF91,MAG,NKX6-2,FA2H,CNTN2,TMEM98,CD9,NDE1,MYO1D,ABCA2,BOK,SYNJ2,DAAM2,WHRN,SFRP1,SOX10
GO:BP Lipid biosynthetic process GO:0008610 0.023671623 1.62577197 711 155 19 17906 SLC45A3,PLP1,UGT8,ELOVL1,PLPP2,FA2H,SLC44A1,PIP4K2A,P2RX7,CYB5R2,CERS2,PLD1,GAL3ST1,ABCA2,ACSL1,SYNJ2,GPD1,FGF1,PLAAT3
GO:BP Regulation of cell development GO:0060284 0.027719447 1.55721544 991 166 24 17906 LRP2,SLC45A3,KLK6,SPP1,ASPA,DOCK5,C21ORF91,MAG,S1PR5,NKX6-2,CNTN2,TMEM98,SEMA4D,CERS2,ZNF536,SEMA6A,SEMA3B,MAN2A1,DAAM2,KIF13B,SFRP1,SOX10,MAP4K4,LTK
GO:BP Positive regulation of bleb assembly GO:1904172 0.028707127 1.54201028 2 71 2 17906 ANLN,P2RX7
GO:BP Regulation of bleb assembly GO:1904170 0.028707127 1.54201028 2 71 2 17906 ANLN,P2RX7
GO:BP Galactosylceramide metabolic process GO:0006681 0.029707822 1.52712919 9 105 3 17906 UGT8,FA2H,GAL3ST1
GO:BP Negative regulation of cell development GO:0010721 0.029857665 1.52494416 350 160 13 17906 SPP1,MAG,NKX6-2,CNTN2,TMEM98,SEMA4D,CERS2,ZNF536,SEMA6A,SEMA3B,DAAM2,SOX10,MAP4K4
GO:BP Drug transmembrane transport GO:0006855 0.032057254 1.49407368 75 2 2 17906 LRP2,AQP1
GO:BP Generation of neurons GO:0048699 0.033131105 1.47976408 1574 166 32 17906 LRP2,SLC45A3,PLP1,KLK6,UGT8,SPP1,GLDN,ASPA,C21ORF91,MAG,S1PR5,NKX6-2,CNTN2,DOCK10,TMEM98,USH1C,SEMA4D,TNC,NDE1,CERS2,ZNF536,SEMA6A,SEMA3B,MAN2A1,DAAM2,KIF13B,WHRN,FRYL,SFRP1,SOX10,MAP4K4,LTK
GO:BP Ceramide metabolic process GO:0006672 0.034955601 1.45648322 94 105 6 17906 UGT8,ELOVL1,FA2H,P2RX7,CERS2,GAL3ST1
GO:BP Transmembrane transport GO:0055085 0.038251324 1.41735353 1634 73 19 17906 LRP2,AQP1,PIEZO2,KCNH8,SLC45A3,ABCA8,TMEM144,GJB1,TF,SGK2,TMEM63A,DYSF,SLC5A11,CLCA4,TTYH2,CAPN3,SLC44A1,P2RX7,SLC26A9
GO:BP Cellular component assembly involved in morphogenesis GO:0010927 0.039919771 1.39881196 114 132 7 17906 UGT8,LDB3,CAPN3,CD9,ABCA2,PHLDB1,CFL2
GO:BP Galactolipid metabolic process GO:0019374 0.042258663 1.37408425 10 105 3 17906 UGT8,FA2H,GAL3ST1
GO:BP Regulation of plasma membrane bounded cell projection organization GO:0120035 0.045082781 1.3459893 694 166 19 17906 ANLN,KLK6,ENPP2,SPP1,C21ORF91,MAG,CNTN2,P2RX7,USH1C,SEMA4D,CERS2,PLD1,CDC42EP1,SEMA6A,SEMA3B,KIF13B,SFRP1,MAP4K4,LTK
GO:BP Regulation of cellular component size GO:0032535 0.049709667 1.30355914 383 132 12 17906 AQP1,SPP1,MAG,CNTN2,P2RX7,USH1C,SEMA4D,WIPF1,CDC42EP1,SEMA6A,SEMA3B,CFL2