Fig. 3

Reduced P-cofilin in the hippocampus of 3-month old APP/PS1 mice. A Sample Western blots of hippocampal protein lysate showing reduced protein of P-cofilin, but not total cofilin and LIMK1. B Summary graphs showing no significant difference in LIMK1 protein expression between WT and APP/PS1 mice (WT n = 5 independent experiments from 5 mice, APP/PS1 n = 5 independent experiments from 5 mice, p = 0.350, two-tailed t-test). C Summary graph showing no significant difference in total cofilin protein expression between WT and APP/PS1 mice (WT n = 5 independent experiments from 5 mice, APP/PS1 n = 5 independent experiments from 5 mice, p = 0.524, two-tailed t-test). D Summary graph showing significantly reduced P-cofilin protein level in APP/PS1 compared to WT mice (WT n = 5 independent experiments from 5 mice, APP/PS1 n = 5 independent experiments from 5 mice, p = 0.014, two-tailed t-test). Data are presented as mean ± s.e.m. *p < 0.05, ns = not significant