Fig. 8

Proposed model of the association of cav-1 in the uptake of α-syn. Cav-1 expression increases in the brain with age. Increased cav-1 expression facilitates the uptake of extracellular α-syn, as well as additional Lewy body-like inclusion formation with expressed α-syn inside cells. The phosphorylation of cav-1 is involved in the uptake of α-syn