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Fig. 3 | Molecular Brain

Fig. 3

From: Inhibition of autophagy by CRMP2-derived peptide ST2-104 (R9-CBD3) via a CaMKKβ/AMPK/mTOR pathway contributes to ischemic postconditioning-induced neuroprotection against cerebral ischemia-reperfusion injury

Fig. 3

ST2-104 affects the CaMKKβ/AMPK/mTOR pathway in ischemic brain tissues of MCAO rats. Rats were subjected to 120 min ischemia followed by 24 h reperfusion. Extracts from the sham-operated and ischemic cerebral cortex were separated for immunoblotting. Detection of CaMKKβ, p-AMPK and p-mTOR protein levels using Western blot analysis. Levels of β-actin protein were used as the loading control. Bar represents mean ± SEM from 3 rats in each group. **P < 0.01 vs. Sham group; #P < 0.05, ##P < 0.01 vs. MCAO group with one-way ANOVA with Tukey’s post-hoc test

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Molecular Brain

ISSN: 1756-6606