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Fig. 4 | Molecular Brain

Fig. 4

From: Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply

Fig. 4

Metabolism of C8 and C10 is independent of carnitine palmitoyltransferase I (CPT1) in brain slices. Metabolism of [U-13C]C8 (red/black striped bars) and [U-13C]C10 (orange/black striped bars) in the presence of the CPT1 inhibitor etomoxir in mouse cerebral cortical slices (molecular carbon labeling, MCL, relative to the MCL without etomoxir (control)). [U-13C]C8 and [U-13C]C10 were provided at a concentration of 200 µM in addition to 5 mM d-glucose. Etomoxir was applied at 100 µM. C8: octanoic acid. C10: decanoic acid, GAD: glutamate decarboxylase, GS: glutamine synthetase. Mean ± SEM, n = 6 from individual animals, repeated measures 1-way ANOVA with Bonferroni post hoc test, *p < 0.05

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Molecular Brain

ISSN: 1756-6606