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Fig. 5 | Molecular Brain

Fig. 5

From: Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply

Fig. 5

Astrocyte glutamine derived from metabolism of C8 and C10 is utilized for GABA synthesis in neurons. Metabolism of [U-13C]C8 (red/white striped bars) and [U-13C]C10 (orange/white striped bars) in the presence of the glutamine synthetase (GS) inhibitor MSO in mouse cerebral cortical slices (molecular carbon labeling, MCL, relative to the MCL without MSO (control)). [U-13C]C8 and [U-13C]C10 were provided at a concentration of 200 µM in addition to 5 mM d-glucose. MSO was applied at 5 mM. C8: octanoic acid. C10: decanoic acid, GAD: glutamate decarboxylase. Mean ± SEM, n = 6 from individual animals, repeated measures 1-way ANOVA with Bonferroni post hoc test, *p < 0.05

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Molecular Brain

ISSN: 1756-6606