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Fig. 5 | Molecular Brain

Fig. 5

From: GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis

Fig. 5

Model summarizing the role of GDF11 in adult hippocampal neurogenesis. GDF11 inhibits the proliferation of amplifying progenitors and neuroblasts under normal conditions. In Gdf11cKO mice there is an increased number of these neural precursor cells. GDF11 promotes the differentiation of neuroblasts into immature neurons and in Gdf11cKO mice there are fewer newborn neurons produced. Legend: Green (stem cell), blue (amplifying progenitor), pink (neuroblast), orange (immature neuron), red (mature neuron)

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