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Fig. 3 | Molecular Brain

Fig. 3

From: Anxiolytic effect of GABAergic neurons in the anterior cingulate cortex in a rat model of chronic inflammatory pain

Fig. 3

Chronic inflammatory pain rats reduced the inhibitory presynaptic transmission in the ACC. A Representative images with immunohistochemical staining for c-Fos (red) and GAD65/67 (Green), and the presentative images of c-Fos merged with GAD65/67 in the bilateral ACC of Control and Model groups. The number of GAD65/67 cells per 0.1 mm2 and the co-labeled ratio in the ipsilateral ACC (B) and contralateral ACC (C) of control and model group rats. n = 3–4. *P < 0.05, compared to the Control group. Bar = 50 μm. D The representative showed sIPSCs of PNs in ACC layer V in each group. The cumulative frequency (E) and amplitude (G) histogram of sIPSCs in different groups. The average frequency (F) and amplitude (H) of sIPSCs were statistically analyzed in Control and Model groups. n = 9 or 12 neurons from 3 or 4 rat/group. *P < 0.05, compared to the Control group. All data represent the mean ± SEM,

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