Fig. 8From: Brain-derived neurotrophic factor produced long-term synaptic enhancement in the anterior cingulate cortex of adult miceThe proposed model explains synaptic mechanisms of BDNF-induced chemical LTP in the ACC. A synaptic model for BDNF-induced LTP. BDNF in the ACC enhanced the synaptic transmission through a postsynaptic mechanism by the activation of TrkB receptor and Ca2+-dependent AC1 signal pathway. mGluR, CP-AMPAR, and PKMζ are also involved in the BDNF-induced LTP in the ACC. BNDF likely causes the potentiation by enhancing presynaptic release of glutamate, although we cannot completely rule out the possibility of presynaptic actionBack to article page