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Table 3 SNVs associated with cognitive ability and synaptic plasticity of glutamatergic neurons

From: Association of CaMK2A and MeCP2 signaling pathways with cognitive ability in adolescents

Gene

SNP

Cognitive abilities

Verbal reasoning

Numerical ability

Mechanical reasoning

Space relations

Abstract reasoning

Verbal comprehension

Grammar and language

Perceptual speed and accuracy

GRIN1

rs4880213

        

F = 4.090

P = 0.018

GRIN2B

rs1805502

     

F = 3.827

P = 0.022

 

F = 2.948

P = 0.053

 

GRIN2C

rs3744215

   

F = 4.340

P = 0.013

     

GRIN3A

rs10989589

      

F = 4.081

P = 0.017

  
 

rs3739722

     

F = 3.420

P = 0.033

   

GRIN3B

rs2240154

     

F = 4.423

P = 0.012

   
 

rs4807399

       

F = 3.755

P = 0.024

 
 

rs2240157

   

F = 3.697

P = 0.025

 

F = 3.360

P = 0.035

   
 

rs2285906

 

F = 4.103

P = 0.017

 

F = 4.034

P = 0.018

 

F = 3.543

P = 0.030

   
 

rs10417824

  

F = 3.064

P = 0.047

  

F = 4.454

P = 0.012

  

F = 4.056

P = 0.018

 

rs10401454

 

F = 5.412

P = 0.005

  

F = 3.158

P = 0.043

F = 4.883

P = 0.008

F = 5.123

P = 0.006

F = 5.832

P = 0.003

F = 3.437

P = 0.033

GRIA1

rs548294

   

F = 4.000

P = 0.019

     

CaMK2A

rs2241694

        

F = 3.248

P = 0.041

  1. F, F ratio = Between estimate/within estimate = (SSB/dfb)/(SSW/dfw) SSB, Sum of squares between groups, SSW: Sum of squares within groups; dfb, Between groups degrees of freedom; dfw, Within groups degrees of freedom
  2. P, p < 0.05