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Fig. 5 | Molecular Brain

Fig. 5

From: Electroacupuncture improves repeated social defeat stress-elicited social avoidance and anxiety-like behaviors by reducing Lipocalin-2 in the hippocampus

Fig. 5

EA stimulation at the Baihui (GV 20) and Dazhui (GV 14) acupoints down-regulates astrocyte activation in RSDS-treated mice. After the behavioral tests, the mice were sacrificed, and brain coronal slices were fixed for immunohistochemistry with an anti-GFAP antibody. Representative images were taken from dorsal (A) or ventral (B) hippocampal CA3 areas, and GFAP immunoreactivity was quantified as the percentage of GFAP-positive cells from the mice of the control group, RSDS, RSDS with sham treatment, or RSDS with EA treatment. Quantitative results of the dorsal (C) and ventral (D) hippocampi are presented as the mean ± SEM. (control: n = 16; RSDS: 17; RSDS/Sham: n = 17; RSDS/EA n = 16) One-way ANOVA with a post-hoc Bonferroni test was used to examine the significance of the mean. * p < 0.05 vs. the control group. *** p < 0.001 vs. the control group. # p < 0.05 vs. the RSDS group. ## p < 0.01 vs. the RSDS group. ANOVA: analysis of variance, EA: electroacupuncture, GFAP: glial fibrillary acidic protein, RSDS: repeated social defeat stress, SEM: standard error of mean

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Molecular Brain

ISSN: 1756-6606