Fig. 2
Genetic defects altered the neuronal oscillations. a–d Relative oscillatory power of delta, theta, low gamma, and upper gamma oscillations in 6–10 month- old HC (n = 30) and dCOs (PRNPE200K1, PRNPE200K2, T21, and LRRK2G2019S; n = 29). e Representative connectivity graphs of electrodes based on the inter-electrode correlation of delta, lower gamma, and upper gamma oscillatory power. f–h The weight (based on Pearson’s correlation coefficient) of the connectivity in e (n = 9 to 25). i Representative traces of local field potential (LFP) generated by each organoid line. The right panel is a magnification of the left panel. The bottom panel is a raster plot showing the spikes detected in the corresponding LFP. j The peak amplitudes of LFP. k–n The modulation index of the coupling of delta and theta phases with the amplitudes of the lower gamma oscillations (k, l; n = 30) and amplitudes of upper gamma oscillations (m, n; n = 30). a–d f–h, j–n Measurements were compared to the HC by One-way ANOVA on ranks with Dunnett’s correction for multiple comparisons. Each point on the graphs represents an individual organoid. Bars and error denote mean and SEM. * p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001