Fig. 5
Cre/ROCK2fl/fl mice display changes in spine length among spine subclasses on CA1 pyramidal neurons. Dorsal CA1 (dCA1): a There were no differences in mean spine length of thin, stubby, or mushroom spines between groups. b The lengths of apical spine subclasses were similar between groups. c Basal mushroom spine length was decreased in Cre/ROCK2fl/fl mice (t(11) = 2.563, *p = 0.0264) compared to ROCK2fl/fl mice. d, f Head diameter was similar between groups for d all dendrites combined, or e apical or f basal dendrites. Ventral CA1 (vCA1): g Mean thin spine length was increased in Cre/ROCK2fl/fl mice (t(9) = 2.600, *p = 0.0287) compared to ROCK2fl/fl littermates. h Cre/ROCK2fl/fl mice had increased apical thin spine length (t(9) = 2.707, *p = 0.0241) compared to ROCK2fl/fl littermates. i There were no differences in basal spine lengths of thin, stubby, or mushroom spines between groups. j, l There were no differences in head diameter for j all dendrites combined, or k apical or l basal spines between groups. dCA1: N = 5 ROCK2fl/fl mice (1 M, 4 F) and 8 Cre/ROCK2fl/fl (5 M, 3 F) mice. vCA1: N = 5 ROCK2fl/fl mice (2 M, 3 F) and 6 Cre/ROCK2fl/fl (3 M, 3 F) mice at 8–9 months of age. Unpaired t-tests were used for all comparisons. Each point represents one mouse and the error bars indicate the standard error of the mean. R2fl/fl, ROCK2fl/fl; Cre/R2fl/fl, Cre/ROCK2fl/fl