Fig. 1

Analysis of sleep architecture of DD mice. A Time spent in wakefulness, NREM sleep, and REM sleep in WT mice and DD mice. ZT zeitgeber time. B, C Episode numbers and mean durations of each vigilance state in WT mice and DD mice. D EEG power spectrum of each vigilance state in WT mice and DD mice. Frequency ranges with significant difference in the Bonferroni’s test between WT mice and DD mice are described within each graph. Data represent mean ± SEM. n = 6 mice in each group. ^§P < 0.05; ^§§P < 0.005; ^§§§P < 0.001 [unpaired t-test]; *^,†,‡P < 0.05; **^{,††,‡‡}P < 0.005; ***^{,†††,‡‡‡}P < 0.001 [two-way repeated measures ANOVA followed by Bonferroni’s test; ^† and ^‡ indicate significant main effect of intervention and significant interaction between intervention and time, respectively, in two-way repeated measures ANOVA, and * indicates significance in Bonferroni’s test]