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Table 1 Baseline characteristics of the included patients (n = 60)

From: Integrated genomic and DNA methylation analysis of patients with advanced non-small cell lung cancer with brain metastases

Characteristics Brain Metastasis group (n = 18) Leptomeningial Metastasis group (n = 11) No Central Nervous System-related metastasis group (n = 31)
Sex, n [%]
 Male 14 [78] 7 [64] 23 [74]
 Female 4 [22] 4 [36] 8 [26]
Median age (years) 63 [43–77] 60 [49–67] 64.5 [44–75]
Stage, n [%]
 IV 18 [100] 11 [100] 31 [100]
Histology, n [%]
 Adenocarcinoma 10 [56] 11 [100] 16 [52]
 Squamous 4 [22] 0 6 [19]
 Mixed histology 4 [22] 0 9 [29]
Presence of extracranial metastasis, n [%]
 Yes 5 [28] 10 [91] 31 [100]
 No 13 [72] 1 [9] 0 [0]
Bone metastasis
 Without 16 [89] 2 [18] 17 [55]
 With 2 [11] 9 [82] 14 [45]
Lymph node metastasis
 Without 18 [100] 11 [100] 10 [32]
 With 0 [0] 0 [0] 21 [68]
Pleural metastasis
 Without 17 [94] 8 [73] 22 [71]
 With 1 [5.6] 3 [27] 9 [29]
Lung metastasis
 Without 16 [89] 11 [100] 20 [65]
 With 2 [11] 0 [0] 11 [35]
Liver metastasis
 Without 17 [94] 9 [82] 21 [68]
 With 1 [5.6] 2 [18] 10 [32]
Thyroid metastasis
 Without 17 [94] 11 [100] 31 [100]
 With 1 [5.6] 0 [0] 0 [0]
Adrenal gland metastasis
 Without 18 [100] 9 [82] 31 [100]
 With 0 [0] 2 [18] 0 [0]
Spleen metastasis
 Without 18 [100] 10 [91] 31 [100]
 With 0 [0] 1 [9.1] 0 [0]