Integrated genomic and DNA methylation analysis of patients with advanced non-small cell lung cancer with brain metastases

Table 1 Baseline characteristics of the included patients (n = 60)

Characteristics	Brain Metastasis group (n = 18)	Leptomeningial Metastasis group (n = 11)	No Central Nervous System-related metastasis group (n = 31)
Sex, n [%]
Male	14 [78]	7 [64]	23 [74]
Female	4 [22]	4 [36]	8 [26]
Median age (years)	63 [43–77]	60 [49–67]	64.5 [44–75]
Stage, n [%]
IV	18 [100]	11 [100]	31 [100]
Histology, n [%]
Adenocarcinoma	10 [56]	11 [100]	16 [52]
Squamous	4 [22]	0	6 [19]
Mixed histology	4 [22]	0	9 [29]
Presence of extracranial metastasis, n [%]
Yes	5 [28]	10 [91]	31 [100]
No	13 [72]	1 [9]	0 [0]
Bone metastasis
Without	16 [89]	2 [18]	17 [55]
With	2 [11]	9 [82]	14 [45]
Lymph node metastasis
Without	18 [100]	11 [100]	10 [32]
With	0 [0]	0 [0]	21 [68]
Pleural metastasis
Without	17 [94]	8 [73]	22 [71]
With	1 [5.6]	3 [27]	9 [29]
Lung metastasis
Without	16 [89]	11 [100]	20 [65]
With	2 [11]	0 [0]	11 [35]
Liver metastasis
Without	17 [94]	9 [82]	21 [68]
With	1 [5.6]	2 [18]	10 [32]
Thyroid metastasis
Without	17 [94]	11 [100]	31 [100]
With	1 [5.6]	0 [0]	0 [0]
Adrenal gland metastasis
Without	18 [100]	9 [82]	31 [100]
With	0 [0]	2 [18]	0 [0]
Spleen metastasis
Without	18 [100]	10 [91]	31 [100]
With	0 [0]	1 [9.1]	0 [0]

ISSN: 1756-6606