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Table 2 Details on the 15 differentially methylated blocks shared between patients with brain metastasis [BM) and leptomeningeal metastasis [LM)

From: Integrated genomic and DNA methylation analysis of patients with advanced non-small cell lung cancer with brain metastases

Chromosome number Start End Gene annotation BM vs No CNS LM vs No CNS
Methylation status P value T statistic Methylation status P value T statistic
4 90757454 90757576 SNCA |Promoter Hyper 0.034 2.24 Hyper 0.035 2.34
5 16180211 16180460 MARCH11|Promoter Hyper 0.043 2.13 Hyper 0.007 3.13
5 170736160 170736492 TLX3|Promoter Hyper 0.016 2.52 Hyper 0.005 3.12
5 170736484 170736738 TLX3|Promoter Hyper 0.026 2.34 Hyper 0.003 3.33
7 96632708 96632856 DLX6-AS1|Promoter Hyper 0.022 2.39 Hyper 0.014 2.71
12 54611524 54611763 Intergenic Hyper 0.018 2.58 Hyper 0.028 2.39
16 55090570 55090893 Intergenic Hyper 0.042 2.17 Hyper 0.036 2.34
2 18011761 18011781 Intergenic Hypo 0.028 − 2.27 Hypo 0.025 − 2.40
4 148402563 148402748 EDNRA|Promoter Hypo 0.032 − 2.23 Hypo 0.020 − 2.42
5 87976039 87976329 LINC00461|Promoter Hypo 0.042 − 2.10 Hypo 0.010 − 2.76
15 45421905 45422101 DUOXA1|Promoter Hypo 0.007 − 2.91 Hypo 0.005 − 2.99
17 37856019 37856236 ERBB2|Promoter Hypo 0.036 − 2.16 Hypo 0.000 − 3.87
18 44786740 44787022 Intergenic Hypo 0.004 − 3.13 Hypo 0.014 − 2.58
19 10047644 10047809 OLFM2|Promoter Hypo 0.004 − 3.03 Hypo 0.022 − 2.39
19 13616982 13617171 CACNA1A|Promoter Hypo 0.029 − 2.25 Hypo 0.024 − 2.35
  1. no CNS no central nervous system-related metastasis, hypo hypomethylated status, hyper hypermethylated status
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Molecular Brain

ISSN: 1756-6606