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Table 2 Details on the 15 differentially methylated blocks shared between patients with brain metastasis [BM) and leptomeningeal metastasis [LM)

From: Integrated genomic and DNA methylation analysis of patients with advanced non-small cell lung cancer with brain metastases

Chromosome number

Start

End

Gene annotation

BM vs No CNS

LM vs No CNS

Methylation status

P value

T statistic

Methylation status

P value

T statistic

4

90757454

90757576

SNCA |Promoter

Hyper

0.034

2.24

Hyper

0.035

2.34

5

16180211

16180460

MARCH11|Promoter

Hyper

0.043

2.13

Hyper

0.007

3.13

5

170736160

170736492

TLX3|Promoter

Hyper

0.016

2.52

Hyper

0.005

3.12

5

170736484

170736738

TLX3|Promoter

Hyper

0.026

2.34

Hyper

0.003

3.33

7

96632708

96632856

DLX6-AS1|Promoter

Hyper

0.022

2.39

Hyper

0.014

2.71

12

54611524

54611763

Intergenic

Hyper

0.018

2.58

Hyper

0.028

2.39

16

55090570

55090893

Intergenic

Hyper

0.042

2.17

Hyper

0.036

2.34

2

18011761

18011781

Intergenic

Hypo

0.028

− 2.27

Hypo

0.025

− 2.40

4

148402563

148402748

EDNRA|Promoter

Hypo

0.032

− 2.23

Hypo

0.020

− 2.42

5

87976039

87976329

LINC00461|Promoter

Hypo

0.042

− 2.10

Hypo

0.010

− 2.76

15

45421905

45422101

DUOXA1|Promoter

Hypo

0.007

− 2.91

Hypo

0.005

− 2.99

17

37856019

37856236

ERBB2|Promoter

Hypo

0.036

− 2.16

Hypo

0.000

− 3.87

18

44786740

44787022

Intergenic

Hypo

0.004

− 3.13

Hypo

0.014

− 2.58

19

10047644

10047809

OLFM2|Promoter

Hypo

0.004

− 3.03

Hypo

0.022

− 2.39

19

13616982

13617171

CACNA1A|Promoter

Hypo

0.029

− 2.25

Hypo

0.024

− 2.35

  1. no CNS no central nervous system-related metastasis, hypo hypomethylated status, hyper hypermethylated status