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Fig. 3 | Molecular Brain

Fig. 3

From: Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer’s disease

Fig. 3

Extent of HA and sAPPα expression throughout the dentate gyrus. A Representative expression of HA through the dorsal–ventral extent of the hippocampus of a virally transduced mouse. Scale bar: 5 mm. B Representative expression of sAPPα in a wild-type mouse hippocampus labelled with the 6E10 antibody. C Representative expression of sAPPα in an APP/PS1 mouse hippocampus also labelled with the 6E10 antibody. Note that this antibody directed against the first half of Aβ detects sAPPα but also labels amyloid-beta plaques. Scale bar: 1 mm. D A 40 × image of the sAPPα expression in the granule cell layer of a wild-type mouse. sAPPα is seen in cell bodies and, as expected, diffusely in the neuropil as sAPPα is expected to be secreted from the cells into the extracellular space. Scale bar: 25 µm

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