Fig. 4

sAPPα effects on cell proliferation in the subgranular zone (SGZ). A NeuN (cyan) labelled neurons in the dentate granule cell layer. Scale bar: 100 µm. B Insert from A showing proliferating cells (IdU, red) in the SGZ. Scale bar: 50 µm. C Cluster of proliferating cells (red) in the SGZ labelled by IdU, as indicated by arrows in (B). Scale bar: 50 µm. Bottom panel Results from sAPPα overexpression on proliferation in wild-type (WT) and Tg animals (WT-control vs. Tg-control: 1.84 ± 0.14 vs. 0.54 ± 0.07 cells/mm). ns, not significant; *, p < 0.05; ***, p < 0.001 assessed by two-way ANOVA followed by Tukey’s post-hoc test. Data expressed as mean ± SEM