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Fig. 5 | Molecular Brain

Fig. 5

From: Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer’s disease

Fig. 5

sAPPα effects on cell survival in the DG. A–D top Representative optical sections of CldU immunostaining (yellow, arrows) from control (A and C) and sAPPα-treated mice (B and D). A–D bottom Confocal images triple-labelled with CldU (yellow, arrows), NeuN (red, neurons) and GFAP (blue, astrocytes) in the adult DG. Scale bars: 50 µm. Results of the survival assay (area density of XdU+ cells) in (E) the whole dentate gyrus, (F) the granule cell layer, (G) the hilus, and (H) the molecular layer. Tg, main effect of genotype; sAPPα, main effect of sAPPα treatment as assessed by two-way ANOVA. *p < 0.05. Data expressed as mean ± SEM

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Molecular Brain

ISSN: 1756-6606