Fig. 7

sAPPα effect on cell differentiation. A A representative mosaic confocal image of the dentate gyrus. For all images NeuN is red, GFAP is blue and CldU is yellow. Scale bar: 100 µm. A, below From the top left insert: NeuN labelling, CldU labelling, and merged image showing two NeuN + CldU + cells. Scale bar: 50 µm. B A representative mosaic confocal image of the dentate gyrus. Scale bar: 100 µm. B, below From the top right insert: GFAP labelling CldU labelling, and merged image showing two GFAP + CldU + cells. Scale bar: 50 µm. C Results of the differentiation assay for neurons in the whole dentate gyrus of WT and Tg animals. There was a significant APPα treatment x genotype interaction, *, p < .05. D Results of the differentiation assay for neurons in the granule cell layer of WT and Tg animals. E Results of the differentiation assay for astrocytes in the whole dentate gyrus of WT and Tg animals. F Results of the differentiation assay for astrocytes in the granule cell layer of WT and Tg animals. Tg, main effect of genotype; sAPPα, main of sAPPα treatment as assessed by 2-way ANOVA. ns not significant, *p < .05. Data expressed as mean ± SEM