Fig. 8

sAPPα effects on amyloid plaque load. Amyloid plaques (Congo red) were specific to Tg-control (A) and Tg-sAPPα (B) mice at 11.5 months of age in the hippocampus and cortex (DAPI nuclei, blue). No amyloid plaques were present in WT-control (C) and WT-sAPPα (D) mice the same age. Scale bar: 100 µm. H.f. Hippocampal fissure. E Percentage of area covered by plaques measured across the dentate gyrus, CA1 and the somatosensory cortex for the Tg-control and Tg-sAPPα overexpressing mice. ns not significant, *, p < 0.05 assessed unpaired Student’s t-test. Data expressed as mean ± SEM