Fig. 2

Effect of pharmacogenetic activation of D1-receptor-expressing neurons in the lateral shell or core of the nucleus accumbens on tumor growth. a, b Suppression on the tumor volume by concomitant stimulation of D1-receptor-expressing neurons through activation of hM3Dq in the lateral shell (a) or core (b) of the nucleus accumbens of D1-Cre mice by repeated administration of CNO (3 mg/kg, i.p., t.i.d.) in comparison of those of D1-WT mice (Two-way repeated measures ANOVA with post-hoc Bonferroni test, ^**p < 0.01, ^***p < 0.001 vs. D1-WT/hM3Dq). c, d Effects of concomitant inhibition of D2-receptor-expressing neurons through stimulation of hM4Di in the lateral shell (c) or core (d) of the nucleus accumbens of D2-cre mice by repeated administration of CNO (3 mg/kg, i.p., t.i.d.) on tumor volume in comparison to those in D2-WT mice. Each point represents the mean ± S.E.M. of 4–11 animals