Fig. 2

Linear regression analyses between metabolites and rodent social behavior. a Volcano plot exhibiting a correlation between social preference and the metabolites in the prefrontal cortex. Metabolites with a significant correlation was colored as pink or cyan depending on the quantile of actual Pearson’s coefficient from the permutated values, 95% (P < 0.05) or 97.5% (P < 0.025) respectively. b–d Correlation between mice social preference index and Glu/GABA, tCr or NAA/tCr. Pearson Correlation Coefficients was used to evaluate linear correlations. Each linear regression line is shown with 95% confidence bands (two dotted lines). The degree of significant correlation (P) and goodness of fit (r²) were written in each figure. e Volcano plot exhibiting a correlation between social recognition and metabolites in hippocampus. Metabolites with a significant correlation was colored as pink or cyan depending on the quantile of actual Pearson’s coefficient from the permutated values, 95% or 97.5% respectively. f Correlation between mice social preference index for novel mouse and PCr/tCr