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Fig. 3 | Molecular Brain

Fig. 3

From: Decreased in vivo glutamate/GABA ratio correlates with the social behavior deficit in a mouse model of autism spectrum disorder

Fig. 3

Cntnap2−/− mice exhibit altered levels of metabolites in the prefrontal cortex and hippocampus. a Cntnap2−/− mice showed significantly lower level of Glu/GABA ratio in the prefrontal cortex than Cntnap2+/+ mice. Two-tailed unpaired t-test with Welch’s correction, *P = 0.0111. b Cntnap2−/− mice showed significantly lower level of total Creatine (Creatine + phospho − Creatine) in the prefrontal cortex. Two-tailed unpaired t-test with Welch’s correction, ***P = 0.0001. c Cntnap2−/− mice showed significantly higher level of NAA/tCr ratio in the prefrontal cortex than Cntnap2+/+ mice. Two-tailed unpaired t-test with Welch’s correction, *P = 0.0220. d Cntnap2−/− mice showed a comparable level of PCr/tCr ratio in the prefrontal cortex to Cntnap2+/+ mice. Two-tailed unpaired t-test with Welch’s correction, P = 0.8610. e Cntnap2−/− mice showed a comparable level of Glx (Glutamine + Glutamate) in the prefrontal cortex. Two-tailed unpaired t-test with Welch’s correction, P = 0.7958. f Cntnap2−/− mice showed a comparable level of GABA/Glu ratio in the hippocampus to Cntnap2+/+ mice. Two-tailed unpaired t-test with Welch’s correction, P = 0.8243. g Cntnap2−/− mice showed a comparable level of total Creatine in the hippocampus to Cntnap2+/+ mice. Two-tailed unpaired t-test with Welch’s correction, P = 0.1994. h Cntnap2−/− mice showed a comparable level of NAA/tCr in the hippocampus to Cntnap2+/+ mice. Two-tailed unpaired t-test with Welch’s correction, P = 0.5117. i Cntnap2−/− mice showed a comparable level of PCr/tCr in the hippocampus to Cntnap2+/+ mice. Two-tailed unpaired t-test with Welch’s correction, P = 0.5854. j Cntnap2−/− mice showed significantly higher level of Glx in the hippocampus to Cntnap2+/+ mice. Two-tailed unpaired t-test with Welch’s correction, *P = 0.0478

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