Fig. 3

TKO mice showed hyperactivity in several behavioral tests. TKO mice showed hyperactivity in several behavioral tests indicated on the left end of the rows. a–d Distance traveled during the entire test (a, b), distance traveled during the first minutes (c), distance traveled during the last 10 min (d) for the open field test. e–h Distance traveled during the whole test (e, f), distance traveled during the first minutes (g), and distance traveled during the last 10 min (h) for the elevated plus-maze test. i–l Distance traveled during the whole test (i, j), distance traveled during the first minutes (k), and distance traveled during the last 10 min (l) for the light–dark preference test. All data are presented as the mean ± standard error of the mean (WT mice, n = 17; TKO mice, n = 16). P values for differences between genotypes were determined by Welch’s t-test (b–d, f–h, and j–l) or calculation of genotype effect in two-way repeated-measures analysis of variance (a, e, i)