Genotype | WT | App-KI | ||||
---|---|---|---|---|---|---|
Anesthesia | Air | Desflurane | Sevoflurane | Air | Desflurane | Sevoflurane |
General health check | ||||||
 Body weight (g) | 33.0 ± 0.9 | 31.1 ± 0.8 | 30.3 ± 1.4 | 31.2 ± 0.6 | 30.6 ± 0.6 | 30.7 ± 0.9 |
 Body size (% with average size) | 106.2 ± 2.8 | 100.1 ± 2.6 | 97.6 ± 4.5 | 100.4 ± 2.0 | 98.4 ± 2.0 | 98.7 ± 2.8 |
 Bald patch (% with) | 28.6 | 25.0 | 50.0 | 0.0 | 8.3 | 0.0 |
 Fur (% with normal fur) | 100.0 | 62.5 | 50.0 | 85.7 | 83.3 | 100.0 |
 Crustiness around the nostrils/eyes (% with) | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
 Ear pinna/Footpad color (% with normal color) | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
 Leisons on the feet/tail (% with) | 14.3 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
 Scabs on the tail, rump, back (% with) | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
 Tumor (% with) | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
 Gait (% with normal gate) | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
 Posture (% with normal posture) | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
 Whisker (% with normal whisker) | 42.9 | 50.0 | 66.7 | 71.4 | 83.3 | 75.0 |
Neurological screening test | ||||||
 Ear twich (% with quick response) | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
 Eye blink (% with normal response) | 85.7 | 100.0 | 100.0 | 85.7 | 75.0 | 91.7 |
 Whisker-touch (% with normal response) | 42.9 | 50.0 | 66.7 | 71.4 | 75.0 | 75.0 |
 Postual reflex (% with normal response) | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 91.7 |
 Righting reflex (% with normal response) | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |