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Fig. 3 | Molecular Brain

Fig. 3

From: Hif1α-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model

Fig. 3

Conditional ablation of Hif1α in neuroepithelial cells causes massive apoptosis. Cleaved caspase3+ apoptotic cells (magenta) in coronal sections of the WT (A, C, E, and G) and KO (B, D, F, and H) telencephalon at the indicated embryonic stages are shown. Higher magnification images of the area enclosed by a rectangular dotted line are shown as insets. Scale bars, 200 μm. WT, wild type; KO, knockout. Three (A–D) and four (E–H) independent experiments are performed and one representative image is shown, respectively

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