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Fig. 8 | Molecular Brain

Fig. 8

From: Hif1α-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model

Fig. 8

Vegf functions as the survival factor for deep-layer neurons in non-cell-autonomous manner. pEGFP-CAGS (control) or pCAG-Cre:GFP (Cre:GFP) plasmid was electroporated into neural progenitor cells in one side of telencephalic semisphere of Hif1α flox/flox embryo at E13.5. Cleaved caspase3+ apoptotic cells (magenta) and EGFP+ transfected cells (green) were detected in coronal sections of the cortex at E18.5. Scale bars; 100 μm. Three independent experiments are performed and one representative image is shown, respectively

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