Fig. 1
From: Chicago sky blue 6B inhibits α-synuclein aggregation and propagation
CSB inhibits α-synuclein fibrillation and reduces its toxicity. a CSB inhibits α-synuclein fibrillation in a concentration-dependent manner. CSB was incubated with recombinant human α-synuclein for 9 days, and Thio-T fluorescence assays were performed daily. b TEM analysis of α-synuclein fibrils incubated with different concentrations of CSB or vehicle (DMSO) control. Scale bars: 1 μm (low magnification, top line) and 200 nm (high magnification, bottom line). c Circular dichroism spectra of α-synuclein protein incubated with CSB (0.1 μM, 1 μM and 10 μM) or DMSO (control). d CSB (0.1, 1 and 10 μM) significantly improved the viability of α-synuclein–overexpressing cells. Data are presented as means ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001; one-way ANOVA with Dunnett’s post hoc test)