Fig. 2

Expression of non-intact L1 loci is significantly lower in the frontal cortex of individuals with ALS or ALSND. a There was no significant difference in the level of non-intact L1 expression in the motor cortex of individuals with ALS or ALSND and controls (p = 0.78). b The total expression of non-intact L1 loci is significantly lower in the frontal cortex (p = 0.02) of individuals with ALS or ALSND compared to controls. c, d There is no significant difference in the level of non-intact L1 expression in the cerebellum (p = 0.10) or cervical spinal cord (p = 0.31) of individuals with ALS or ALSND and controls. Motor cortex-ALS/ALSND n = 92 and NNC n = 15, frontal cortex-ALS/ALSND n = 121 and NNC n = 15, cerebellum-ALS/ALSND n = 133 and NNC n = 14 and spinal cord cervical-ALS/ALSND n = 115 and NNC n = 13. ALS amyotrophic lateral sclerosis, ALSND amyotrophic lateral sclerosis and other neurological disorder, NNC non-neurological control, FPM fragments per million