Fig. 3

L1 loci specific expression across four tissues. a The mean expression of each of the 50 intact L1 loci across four tissues (motor cortex, frontal cortex, cerebellum and spinal cord cervical) of individuals with ALS or ALSND and controls. b The mean expression of each of the 42 non-intact L1 loci across four tissues (motor cortex, frontal cortex, cerebellum and spinal cord cervical) of individuals with ALS or ALSND and controls. Motor cortex-ALS/ALSND n = 92 and NNC n = 15, frontal cortex-ALS/ALSND n = 121 and NNC n = 15, cerebellum-ALS/ALSND n = 133 and NNC n = 14 and spinal cord cervical- ALS/ALSND n = 115 and NNC n = 13. ALS amyotrophic lateral sclerosis, ALS amyotrophic lateral sclerosis and other neurological disorder, NNC non-neurological control, FPM fragments per million, *polymorphic L1s