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Fig. 1 | Molecular Brain

Fig. 1

From: Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome

Fig. 1

Administration of OXT improved impaired social interaction in Df/+ mice. a Timeline for the reciprocal social interaction test with OXT treatment. The test was carried out 30 min after administration of OXT (200 µg/kg) or saline. OXT, Oxytocin. b Social interaction time in the reciprocal social interaction test (each n = 12). The time spent sniffing, following, allo-grooming, and push-crawling of test mice toward the intruder was measured as social interaction time (two-way ANOVA for genotype, F1,44 = 8.84, P = 0.0048; for treatment, F1,44 = 4.61, P = 0.037; genotype × treatment interaction, F1,44 = 3.23, P = 0.079). WT, wild-type. c (upper) Schematic illustration of the PVN (green) and (lower) representative images of OXT-Neurophysin1 immunostaining (green) and hoechst33258 staining (blue) in the PVN of adult Df/+ mice and WT littermates. Scale bar, 100 μm. d Quantification of the number of OXT-positive cells in the PVN (each n = 4 mice). e ELISA quantification of the OXT concentration in the cerebral cortex extract (each n = 8 mice). f Quantitative real-time RT-PCR analysis of the expression levels of Oxtr and Avpr1a mRNA (each n = 4 mice). Oxtr, OXT receptor; Avpr1a, vasopressin receptor 1 A. Data are represented as the mean ± SEM. Statistical significance was analyzed by a two-way ANOVA, followed by Bonferroni Dunn post hoc tests (b) and Student’s t-test (d–f). *P < 0.05, ****P < 0.0001, n,s, not significant

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