Fig. 6

CTCF-cKO mice display increase in Kv3.1, potassium ion channel, in PV neurons and increased sIPSC frequency and amplitude in hippocampal pyramidal neurons. A CTCF- cKO mice exhibit elevation in the Kv3.1 florescence intensity in PV neurons in the prelimbic prefrontal cortex (*p = 0.047) and the hippocampal CA2-CA3 (**p = 0.008). B–E sIPSC recordings in the pyramidal neurons from acute hippocampal slices of 8 weeks old mice. B Cumulative probability plots reveal a leftward shift in the sIPSC inter-event intervals (Kolmogorov–Smirnov test, ****p < 0.0001) and a C rightward shift in the sIPSC amplitudes (Kolmogorov–Smirnov test, ****p < 0.0001) in the cKO mice compared to their WT littermates. D Average frequency (*p = 0.024) and E amplitude (**p = 0.004) are increased in the pyramidal neurons of the cKO mice when compared to their WT controls. WT, n = 31 neurons, 4 animals; cKO, n = 36 neurons, 4 animals. Values in graphs are expressed as the mean ± SEM