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Fig. 1 | Molecular Brain

Fig. 1

From: Antiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model

Fig. 1

KDS2010 reduced PTX-induced mechanical hypersensitivity with minimal side effects. A Paw withdrawal frequency (PWF %) was compared among the control, paclitaxel (PTX), and KDS2010 (PTX + KDS) groups at the indicated time points. PTX induced mechanical hypersensitivity peaked at day 12 after the first injection and continued until at least day 38. KDS2010 significantly reduced PTX-induced mechanical hypersensitivity in a concentration-dependent manner. B The area under the curve (AUC) of PWF from 14 to 26 days. C The body weight of the mice was monitored throughout the experimental time course. D The area under the curve for body weight, from 20 to 24 days. All data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.01 compared to PTX-treated group, #P < 0.05 compared to control

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Molecular Brain

ISSN: 1756-6606