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Fig. 2 | Molecular Brain

Fig. 2

From: Antiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model

Fig. 2

KDS2010 prevented and suppressed PTX-induced tactile hypersensitivity. Frequency of paw withdrawal responses (%) in the von Frey filament tests was measured at different time points in the control, PTX, and KDS2010 (PTX + KDS) groups. A KDS2010 had significant reversible effects on PTX-induced tactile hypersensitivity. Similar anti-allodynic effects were observed with the second application of KDS2010 (31–41 days) in the same group. B Co-treatment with KDS2010 had similar reversible effects on PTX-induced tactile hypersensitivity, as shown in (A). All data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.01 compared to the PTX-treated group

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Molecular Brain

ISSN: 1756-6606