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Fig. 5 | Molecular Brain

Fig. 5

From: Antiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model

Fig. 5

Paclitaxel-induced altered tonic GABAA inhibition and GAT1 expression were not reversed by KDS2010. A Representative traces of tonic current in recorded in substantia gelatinosa (SG) neurons in control, PTX-, and KDS2010 (PTX + KDS)-treated mice. Tonic current was significantly reduced by PTX, and KDS2010 failed to reverse this effect. B Bar graph summarizing the mean tonic current amplitude. C Representative image of Western blot showing GAT-1 expression in the spinal cord of the control, PTX-, and KDS2010 (PTX + KDS)-treated mice. D Relative expression of GAT-1, shown by bar graphs. All data are presented as mean ± SEM. *P < 0.05, compared to control group

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Molecular Brain

ISSN: 1756-6606