Fig. 2

mRNA profile based on RNA-seq data. A Distribution of all identified mRNA in TBI samples. B Volcano plot of DEmRNAs in mice cortex 24 h post-TBI compared with control cortex. Red points represent upregulated DEmRNAs and blue points represent downregulated DEmRNAs in TBI group. The genesymbols of ten upregulated mRNAs and ten downregulated mRNAs with the most significant expression differences are shown in the plot. C Hierarchical cluster heatmaps of DEmRNAs. Each row represents an RNA, and each column represents a sample. Red indicates relatively high expression, and blue indicates relatively low expression. D Distribution of DEmRNAs in TBI, showing upregulated (gray) and downregulated (black) mRNAs in each chromosome (chr)