Fig. 4

A The top 20 enriched terms in the GO biological process analysis. B PPI network of mRNAs in ceRNA network. Circles represent protein-coding genes, and edges represent the interactions between two proteins. The purple circles represent top 10 hub genes with highest degrees. C–J Validation of expression differences of DElncRNAs and DEmRNAs via qRT-PCR. C–D P2ry12 and Hes5 expression significantly decrease in injury cortex 24 h post-TBI compared to control cortex. E–F Cxcr2 and Mmp12 expression significantly increase in injury cortex 24 h post-TBI compared to control cortex. G–H lncRNA C030018K13Rik and Gm36823 expression significantly decrease in injury cortex 24 h post-TBI compared to control cortex. I–J lncRNA H19 and Mir155hg expression significantly increase in injury cortex 24 h post-TBI compared to control cortex. All the experiments were performed and analyzed in triplicate. (*P < 0.05, **P < 0.01, ***P < 0.001)