Fig. 3
[3H]-UCB-J binding level in cortex tissue and correlation of SV2A mRNA level with [3H]-UCB-J binding. Quantitative autoradiographic measurements of cortical [3H]-UCB-J density is expressed as specific binding in nCi/mg tissue in cortex of TLE (temporal lobe epilepsy) patients (n = 10) and non-epileptic postmortem controls (n = 9) (Student’s t-test; p < 0.001, t = 5.506, df = 17, 95% confidence interval). All the values are in Mean ± SD (A). Positive correlation between SV2A gene expression levels and [3H]-UCB-J binding levels of patients (n = 10, r = 0.72, p = 0.018, 95% confidence interval). r represents the Pearson’s correlation coefficient. p < 0.05 is considered statistically significant for all comparisons. Investigated correlations were linear. B Four different representative autoradiogram images of cortex from both TLE patients and controls. Non-specific binding was shown with 10 mM levetiracetam addition to incubation solution of adjacent slice (C)