Fig. 4From: Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disordersSchematic diagram showing mutations in several genes i.e. presenilin-1(PSEN1), presenilin-2 (PSEN2), amyloid-beta precursor protein (APP), apolipoprotein (APOE3), and apolipoprotein 4 (APOE4) related to increase risk of neurological disorders. Alzheimer’s disease (AD) is caused by mutations in the above genes and also by hyperphosphorylation of tau proteins in the distal part of axons in neuronal cells results in NFTs and cell deathBack to article page