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Fig. 6 | Molecular Brain

Fig. 6

From: Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders

Fig. 6

Key pathological characteristics of Parkinson’s disease (PD) are depicted. These include cell death in the Substantia Nigra and Lewy bodies [aggregation of α-synuclein (α-syn),] affecting dopamine releasing neurons. BBB breakdown leads to accumulation of various blood components, leading to production of ROS and thus affecting dopaminergic astrocytes and neurons in case of PD. This figure is adapted from [118]

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Molecular Brain

ISSN: 1756-6606