Skip to main content
Fig. 7 | Molecular Brain

Fig. 7

From: Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders

Fig. 7

Transport pathways/routes allowing accessibility across BBB. A Passive transcellular diffusion/dispersion: Passive diffusion of solutes across BBB is facilitated by higher solubility of lipids. B Active efflux of penetrating solutes out of ECs is mediated via efflux carriers C Modulation of TJs affects the paracellular diffusional pathway permeability. D Carrier-mediated transcytosis system transport several essential polar molecules into CNS like glucose, nucleosides, etc. E Macromolecules such as proteins and regulatory molecules, across the cerebral endothelium can be directed via receptor mediated transcytosis. F Paracellular pathway is used by small water-soluble molecules for movement across CNS. G Adsorptive mediated transcytosis is induced by cationic macromolecules which aid movement across BBB. The idea of the figure is adapted from [164]

Back to article page

Molecular Brain

ISSN: 1756-6606