Fig. 4From: Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in miceEffects of CDK5 knockdown on dendrite length and spine density of DS neurons. A Upper panel: Representative Golgi staining of dendrites in the DS of WT, DS-CDK5-NC, and DS-CDK5-KD mice; Lower panel: 8-bit neuron tracing images. Scale bar = 20 µm. B–D Quantification of dendrite length and branching of MSN tracing images. E Representative photographs of MSN dendrite segments from the DS of WT, DS-CDK5-NC, and DS-CDK5-KD mice. F Cell counter for spine density analysis. n = 10–20 MSNs/segment from four slices of two animals per group. ANOVA analysis showing a reduction in dendrite length, branching, and spine density in DS-CDK5-KD mice compared with those in WT and DS-CDK5-NC mice. Data are represented as the mean ± SEM. One-way ANOVA, Tukey’s multiple comparisons test, *p < 0.05, **p < 0.01, ***p < 0.001 vs WTBack to article page