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Fig. 4 | Molecular Brain

Fig. 4

From: Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice

Fig. 4

Effects of CDK5 knockdown on dendrite length and spine density of DS neurons. A Upper panel: Representative Golgi staining of dendrites in the DS of WT, DS-CDK5-NC, and DS-CDK5-KD mice; Lower panel: 8-bit neuron tracing images. Scale bar = 20 µm. BD Quantification of dendrite length and branching of MSN tracing images. E Representative photographs of MSN dendrite segments from the DS of WT, DS-CDK5-NC, and DS-CDK5-KD mice. F Cell counter for spine density analysis. n = 10–20 MSNs/segment from four slices of two animals per group. ANOVA analysis showing a reduction in dendrite length, branching, and spine density in DS-CDK5-KD mice compared with those in WT and DS-CDK5-NC mice. Data are represented as the mean ± SEM. One-way ANOVA, Tukey’s multiple comparisons test, *p < 0.05, **p < 0.01, ***p < 0.001 vs WT

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