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Fig. 5 | Molecular Brain

Fig. 5

From: Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice

Fig. 5

CDK5 deficiency reduces the expression of PSD-95, MAP2, synapsin 1 and Tau phosphorylation in the DS. A Representative blots of PSD-95, MAP2 and synapsin I from the DS of WT, DS-CDK5-NC, and DS-CDK5-KD mice. B ANOVA analysis of relative protein levels of PSD-95, MAP2 and synapsin 1. C Representative blots of total Tau and phosphorylated Tau at Thr181 and Ser202 from the DS of WT, DS-CDK5-NC, and DS-CDK5-KD mice. D ANOVA of relative Tau, p-Tau Ser202, and p-Tau Thr181 levels. Data are represented as the mean ± SEM, n = 6–8 independent experiments. One-way ANOVA, Tukey’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001 vs WT

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