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Fig. 8 | Molecular Brain

Fig. 8

From: Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice

Fig. 8

Proposed consequences of CDK5 loss on DS neuronal transmission. Compared with WT mice, shown on the left side, mice with CDK5 knockdown exhibit reduced dendrite length and synapse density associated with downregulation of MAP2, PSD-95, synapsin 1, and p-Tau Thr181 in the DS. This results in impaired neuronal signaling and reduced long-range projections from the DS to M2, thalamus, and BLA

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Molecular Brain

ISSN: 1756-6606