Fig. 4
From: Genome-wide translation control analysis of developing human neurons
Translational Control of neuronal metabolic genes involved in Glycolysis, TCA, Urea cycle, and glutamate metabolism. A TE Heatmap showing significantly regulated genes (TE FC > 2, FDR < 0.01) involved in glycolysis, TCA cycle, and glutamate metabolism in Neurons. B Glycolysis, TCA, Urea cycle, and glutamate/GABA metabolic map. Gray: No regulation in neurons; Blue: Up-regulated genes; Red: Down-regulated genes; Dark blue: Translationally induced genes; Dark Red: Translationally repressed genes; Black: RNA Down, TE Up genes; Green: RNA up, TE down genes. Circles: Riboseq FC Heatmap for each gene. C ARG2, GOT1, and OAT and SRM mRNA are more associated with heavy polysomes in neurons; meanwhile, SRM is more associated with heavy polysomes in NPCs. The graphic represents an average of 3 independent experiments. Asterisks indicates: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001