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Fig. 2 | Molecular Brain

Fig. 2

From: mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination

Fig. 2

Conditional knock-out of Rptor in PV interneurons impairs firing properties. A and B Summary bar graphs showing intact: resting membrane potential (A) and input resistance (B) of CA1 PV interneurons from PV-Raptor-Het (green) and PV-Raptor-Homo (red) relative to PV-Raptor-WT mice (black). C Representative voltage responses of PV interneurons in response to a somatic depolarization (260 pA), illustrating the decrease in evoked firing of PV cells from PV-Raptor-Het and PV-Raptor-Homo mice relative to PV-Raptor-WT mice. D Summary plot of frequency-current relationship for all cells showing reduced evoked firing of PV interneurons from PV-Raptor-Homo (n = 11 cells, 3 mice) and PV-Raptor-Het (n = 10 cells, 3 mice) mice relative to PV-Raptor-WT mice (n = 9 cells, 4 mice). E–I Summary bar graphs showing intact: action potential amplitude (E), action potential latency (F), action potential threshold (G), action potential half-width (H) and fast after-hyperpolarization amplitude (I) of CA1 PV interneurons from PV-Raptor-Het (green) and PV-Raptor-Homo (red) relative to PV-Raptor-WT mice (black). * p < 0.05, **** p < 0.0001, ns not significant

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