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Fig. 1 | Molecular Brain

Fig. 1

From: Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8+ T cells

Fig. 1

Distinguishing indicators and regulators of ferroptosis in different brain regions of ECM mice. a and b MDA levels (a) and Fe contents (b) in the cerebrum and brainstem of control and ECM mice were measured using a commercial kit. c Expression of TfR1, ACLS4, and GPX4 in the olfactory bulb, cerebrum, cerebellum, and brainstem of control and ECM mice was measured by western blotting. Relative quantitative analysis was performed densitometry. d mRNA expression of tfrc, acsl4, and gpx4 in the olfactory bulb, cerebrum, cerebellum, and brainstem of control and ECM mice was measured by quantitative real-time polymerase chain reaction. Relative expression is shown as fold-change in relation to control levels. Data are reported as mean ± standard deviation. Each point represents one animal. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. control. ACSL4 acyl-CoA synthetase long-chain family member 4, ECM experimental cerebral malaria, GPX4 glutathione peroxidase 4, MDA malondialdehyde, TfR1 transferrin receptor 1

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